Based on the current knowledge and our Team’s many years of experience in organic synthesis and development of active substance production processes, we offer the following R&D services:
- synthesis of structurally complex organic compounds
- synthesis of compound libraries
- route scouting
- development and optimisation of the synthesis process
- development of analytical methods for controlling the course of reactions
- scale-up
- determination of critical process parameters
- troubleshooting
- technology transfer to the production facility
- production of the active substance*
- stability testing (initial or GMP*)
- identification of impurities, synthesis and standard setting
- preparation of the relevant sections of regulatory documents (Investigational Medicinal Product Dossier, Module 3)
When it comes to synthesis, we offer the following:
- synthesis scale: from mg to kg
- reactor volume: up to 20 l
- multi-step syntheses
- organometallic reactions
- asymmetric synthesis
- synthesis of heterocyclic compounds
- synthesis of compound libraries
- synthesis of compounds labelled with stable isotopes
- development of flow processes
- discovery and characterisation of polymorphs*
* services provided in cooperation with Business Partners